TONE NOTES · A MELASMA READING GUIDERESEARCHED OCTOBER 2026
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Our source library

THE RESEARCH

Sources & further reading

Provider pages establish what a brand markets. Clinical and regulatory sources establish the limits of the evidence. Each source has its own last-checked date below.

  1. CoreAge Rx: Spot OnOfficial source; checked October 8, 2026 · Checked October 8, 2026
  2. CoreAge Rx: catalog and consultation termsOfficial source; checked October 8, 2026 · Checked October 8, 2026
  3. Musely: The Spot CreamOfficial source; checked October 8, 2026 · Checked October 8, 2026
  4. Agency: Dark Spot RxOfficial source; checked October 8, 2026 · Checked October 8, 2026
  5. DailyMed: current TRI-LUMA prescribing informationGalderma drug labeling; current accessible version checked October 8, 2026 · Checked October 8, 2026
  6. Cyspera: Intensive US product pageOfficial source; checked October 8, 2026 · Checked October 8, 2026
  7. AAD: melasma diagnosis and treatmentAAD guidance rechecked October 10, 2026. · Checked October 10, 2026
  8. AAD: melasma self-careAAD guidance rechecked October 10, 2026. · Checked October 10, 2026
  9. FDA: compounding questions and answersOfficial source; checked October 8, 2026 · Checked October 8, 2026
  10. FDA: warnings about skin-lightening productsOfficial source; checked October 8, 2026 · Checked October 8, 2026
  11. Lima et al.: 5% cysteamine versus 4% hydroquinone2020 trial; 40 women; not a trial of the current 7% Cyspera Intensive formula · Checked October 8, 2026
  12. AAD: pregnancy skincareOfficial source; checked October 8, 2026 · Checked October 8, 2026
  13. SkinCeuticals: Discoloration Defense and study protocolsUS product page: $115 / 30 mL. Two manufacturer study protocols include concurrent sunscreen use. · Checked October 10, 2026
  14. Eucerin: Radiant Tone Dual SerumUS formula and 1 fl oz size; retailer price not verified. The extracted percentage claim lacked sufficient method details for an efficacy comparison. · Checked October 10, 2026